Network Organization Unfolds over Time during Periods of Anxious Anticipation

Network organization unfolds over time during periods of anxious anticipation.

Entering a state of anxious anticipation triggers widespread changes across large-scale networks in the brain. The temporal aspects of this transition into an anxious state are poorly understood. To address this question, an instructed threat of shock paradigm was used while recording functional MRI in humans to measure how activation and functional connectivity change over time across the sali...

Dynamics of Intersubject Brain Networks during Anxious Anticipation

How do large-scale brain networks reorganize during the waxing and waning of anxious anticipation? Here, threat was dynamically modulated during human functional MRI as two circles slowly meandered on the screen; if they touched, an unpleasant shock was delivered. We employed intersubject correlation analysis, which allowed the investigation of network-level functional connectivity across brain...

Anxious Anticipation of a Social Threat and its Effect on Time Estimation

Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation.

Anticipation is a central component of anxiety and the anterior insula appears to be an important neural substrate in which this process is mediated. The anterior insula is also thought to underlie the interoceptive representation of one's affective state. However, the degree to which individual differences in anticipation-related insula reactivity are associated with variability in the subject...

Optimising patient recall of adverse events over prolonged time periods

Objectives Large, simple, pragmatic, low-risk, maintenance treatment trials may seem straightforward to design, run and analyse. However, if trial case record forms (CRFs) are completed infrequently, the reliability of patient recall over these long time-periods is questionable, especially when recording individual incidences and severity of toxicities of specific interest to the trial. It is e...